The objective of this research was to improve the physicochemical properties of mosapride citrate (MSP) with an ultimate goal to increase its bioavailability. In order to achieve this goal, MSP-pharmacosomes were prepared by refluxing MSP and phospholipids at different temperatures, for different times and using different mosapride: phosphatidylcholine (PC) molar ratios. The yield % of prepared MSP-pharmacosomes was evaluated to determine the best preparation conditions. The best formula was characterized regarding N-octanol/water partition coefficient, N-octanol solubility; water solubility, FT-IR, differential scanning calorimetry (DSC), X-ray diffraction (XRD) morphology and particle size. Results revealed that reaction temperature 60°C for reaction time of 2 hrs using MSP: PC molar ratio 1:2 was the optimum conditions for MSP-pharmacosomes preparations. The prepared MSP-pharmacosmes partition coefficient was higher than MSP material. MSP-pharmacosomal dispersion in water had a small particle size in nano range. Accordingly, MSP-pharmacosomes could be a promising approach for improving physicochemical properties of mosapride citrate to increase its bioavailability.
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